Serious cardiovascular events, including myocardial infarction, sudden cardiac death, unstable angina pectoris, ventricular arrhythmia, stroke, transient ischaemic attacks, chest pain, palpitations and tachycardia, have been reported either post marketing and/or in clinical trials. Most of the patients in whom these events have been reported had pre-existing cardiovascular risk factors. However, it is not possible to definitively determine whether these events are related directly to these risk factors, to CIALIS, to sexual activity, or to a combination of these or other factors. levitra order Warnings and PrecautionsGeriatrics: Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma AUC values of sildenafil and its active N-desmethyl metabolite, respectively, compared to those seen in healthy younger volunteers (18–45 years). Due to age-differences in plasma protein binding, the corresponding increase in the AUC of free (unbound) sildenafil and its active N-desmethyl metabolite were 45% and 57%, respectively [see Dosage and Administration (2.5), and Use in Specific Populations (8.5)]
Levitra can also cause sudden loss of vision by decreasing the flow of blood to the optic nerve in the eye. This occurrence is mostly exhibited in people suffering from heart disease, high cholesterol, high blood pressure, diabetes or other eye problems, and thus should you be suffering from these, it is essential that you consult your doctor before using the drug. This loss in vision may also occur if you are over 50 years of age and in the habit of smoking regularly. Bloody nose
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Recuerde, mantenga ésta y todas las otras medicinas fuera del alcance de los ni?os, no comparta nunca sus medicinas con otros, y use este medicamento sólo para la condición por la que fue recetada.Excretion — The mean oral clearance for tadalafil is 2.5 L/hr and the mean terminal half-life is 17.5 hours in healthy subjects. Tadalafil is excreted predominantly as metabolites, mainly in the feces (approximately 61% of the dose) and to a lesser extent in the urine (approximately 36% of the dose).
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