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CrCl <30 mL/min: Not recommendedDosage adjustment is necessary in patients with moderate hepatic impairment.
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Caution is advised when PDE5 inhibitors are coadministered with alpha-blockers. PDE5 inhibitors, including Cialis, and alpha-adrenergic blocking agents are both vasodilators with blood-pressure-lowering effects. When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. In some patients, concomitant use of these two drug classes can lower blood pressure significantly [see Drug Interactions (7.1) and Clinical Pharmacology (12.2)], which may lead to symptomatic hypotension (e.g., fainting). Consideration should be given to the following: buy cialis online uk If you accidentally take too much Viagra, call your doctor or go to the nearest hospital emergency room right away.
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